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Aurum Pharmaceuticals - Smart Depo


Are you or a loved one struggling with alcohol or other drugs? You’re not alone.

Reach out now. We’re here for you. We can help.

Hope has a home.

AURUM Pharmaceuticals scientists are developing new medications to treat stimulant (cocaine, methamphetamine), alcohol and opioid addiction.

We are committed to helping you find freedom from addiction. Whether you have one month or one decade of recovery, our post treatment resources and services can help you continue to grow your recovery. We can give you practical, effective help to improve the quality of your life, work and relationships.

It’s time to get your life back.

NALMEFENE CONSTA® is supplied as a microsphere formulation of Nalmefene. The active ingredient in NALMEFENE CONSTA® (SmartDepot – Nalmefene extended-release injection) — Nalmefene — is a drug that reverses the effects of opioids. Nalmefene works as a “blocker”. The blockade of opioid receptors is the basis behind Nalmefene’s action in the management of opioid dependence… More

TEMPOSIL CONSTA® is supplied as a microsphere formulation of Temposil. The active ingredient in TEMPOSIL CONSTA® (SmartDepot – Temposil extended-release injection) — Temposil — is an alcohol sensitizing agent. In the body, alcohol is converted to acetaldehyde, which is then broken down by aldehyde dehydrogenase. Its effects that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. If the dehydrogenase enzyme is inhibited, acetaldehyde builds up and causes unpleasant effects. It causes unpleasant effects when even small amounts of alcohol are consumed… More

VANOXERINE CONSTA® is supplied as a microsphere formulation of Vanoxerine. The active ingredient in VANOXERINE CONSTA® (SmartDepot – Vanoxerine extended-release injection) — Vanoxerine — is an antagonist of dopamine transporter (DAT1) with Ki value of 16.9nM. Vanoxerine, is a potent and selective dopamine reuptake inhibitor (DRI). Vanoxerine binds to the target site on the… More

Smart Depot

SmartDepot is a next generation technology featuring various release profiles from 1 week to several months. SmartDepot is ultrasonic spray drying technology for the preparation of sustained release (SR) injectable microsphere formulation of drug. Once the drug is injected, microspheres appear around the muscles. The microspheres, sized about 5 to 50 ㎛, consists of a drug and PLGA/PLA biodegradable polymer as releasing controller. As the polymers of microspheres are gradually biodegraded, the injected drug is slowly released into veins. When all of the microspheres are degraded, the drug's effectiveness is diminished. The duration of the release may be adjusted depending on the size of the microspheres and the characteristics of the polymers. Drug manufactured through SmartDepot, with its sustained release, may remain effective for a long period of time with only a single shot. This will prove to be a great convenience for patients who are required to take drugs for a long period of time.

SmartDepot has excellent bioavailability compared with existing SR technologies. Since same therapeutic efficacy can be achieved with relatively smaller quantity of active pharmaceutical ingredient through this technology, products manufactured by this technology have a lower risk of side effects but higher cost effectiveness. SmartDepot is able to keep one dose of medication effective for a significant period of time. SmartDepot is able to control the release time of drugs.